Is Crealine Defensive suitable for sensitive or acne-prone skin?

Yes, the formula is designed as a soothing barrier-repair cream and is free of fragrance and heavy occlusive oils, so it is generally well tolerated by sensitive and acne-prone skin, although the presence of butylene glycol, acrylate polymers and soy-derived oil may still cause irritation in highly reactive individuals.

What does Palmitoyl Tetrapeptide-10 do in Crealine Defensive?

Palmitoyl Tetrapeptide-10 (also known as BI 2012) is a synthetic peptide that stimulates collagen production and strengthens the skin barrier, helping to reduce visible signs of irritation and improve firmness with regular use.

How often should Crealine Defensive be applied and does it contain any controversial ingredients?

The cream can be applied twice daily, morning and evening, after cleansing, or more frequently on areas of intense irritation; its formulation avoids parabens and silicones but includes acrylate polymers, butylene glycol and soy-derived oil, which some consumers consider less desirable or potential irritants.

Bioderma • 40 ml

Créaline Défensive

Face

Product Insights

Crealine Defensive is a 40 ml soothing face cream from the French dermatological brand Bioderma, formulated to calm irritated skin and reinforce the skin barrier. The water-based base combines humectants such as glycerin and pentylene glycol with emollients like squalane, mango seed butter and propylheptyl caprylate, while actives such as carnosine, tocopherol, salvia miltiorrhiza extract and the peptide Palmitoyl Tetrapeptide-10 support antioxidant protection and barrier repair. Potential drawbacks are the inclusion of acrylate polymers, butylene glycol and soy-derived oil, which can irritate very sensitive or allergic skin, and the vegan status of the formula remains unclear.

Comparative Analysis

Positioned as a calming barrier-repair cream, Bioderma Crealine Defensive competes with other dermatologist-developed soothing moisturizers such as La Roche-Posay Cicaplast Baume B5 and Avene Cicalfate, distinguishing itself with the addition of Palmitoyl Tetrapeptide-10 and mango seed butter for extra nourishment.

Ingredients

AQUA/WATER/EAU, GLYCERIN, DICAPRYLYL ETHER, PROPYLHEPTYL CAPRYLATE, BUTYLENE GLYCOL, GLYCERYL STEARATE CITRATE, GLYCOL PALMITATE, SQUALANE, SUCROSE STEARATE, MANGIFERA INDICA (MANGO) SEED BUTTER, PENTYLENE GLYCOL, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, CAPRYLYL GLYCOL, CARNOSINE, HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER, MANNITOL, XYLITOL, TOCOPHEROL, SALVIA MILTIORRHIZA FLOWER/LEAF/ROOT EXTRACT, RHAMNOSE, GLYCINE SOJA (SOYBEAN) OIL, POLYSORBATE 60, SORBITAN ISOSTEARATE, PALMITOYL TETRAPEPTIDE-10. [BI 2012]

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